The kit enables genomic, transcriptomic, and proteomic analysis from a single sample to support cancer and disease research.
Thermo Fisher Scientific has introduced the Thermo Scientific Sequential Protein/DNA/RNA Extraction Kit, a sample preparation solution that enables sequential extraction of protein, DNA, and RNA from a single sample.
The kit is designed to address challenges in cancer and disease research where samples are often limited and difficult to replace. By allowing researchers to generate genomic and prsoteomic data from the same biological material, the solution helps enable more direct comparison of results from small or precious samples.
“What I really loved about the Sequential Protein/DNA/RNA Extraction Kit is how the magnetic bead workflow let me easily recover proteins, RNA, and DNA in solution without any centrifugation, automate the entire process if I wanted to, and use the purified material immediately for downstream applications,” says Dr Osamu Ohara, head of the department of applied genomics, biophysics and clinical-omics at Kazusa DNA Research Institute in Japan, in a release.
Supporting Multi-Omics Research Workflows
The kit is intended to support research workflows that seek to better understand biological mechanisms underlying disease by connecting genetic variation, gene expression, and protein-level activity. Purified protein is suitable for downstream mass spectrometry analysis, while extracted DNA and RNA are compatible with next-generation sequencing applications.
As research increasingly relies on small biopsies, rare cell populations, and other precious samples, the Sequential Protein/DNA/RNA Extraction Kit is designed to help researchers make more effective use of limited material while maintaining consistency across downstream analyses.
The solution targets researchers studying cancer and disease biology, where understanding how genetic variation, gene expression, and protein activity interact is critical to advancing scientific insight. These studies often rely on small or precious cell and tissue samples, such as biopsies or rare cell populations, making it challenging to perform multiple molecular analyses from a single specimen.
Addressing Sample Limitations
“In cancer and disease research, samples often come from patients through procedures that can be difficult or invasive, and researchers may only have one opportunity to learn from them,” says Malin Karlsson, senior director, general manager, CEP & Beads, Life Sciences Solutions Group, Thermo Fisher Scientific, in a release. “Being able to analyze protein, DNA, and RNA from the same sample allows scientists to make the most of that material and better connect molecular changes, without having to choose one type of analysis over another.”
The kit produces purified DNA and RNA suitable for next-generation sequencing and protein suitable for mass spectrometry, supporting commonly used genomic and proteomic research workflows. It is designed specifically for research involving small or difficult-to-replace samples where dividing material across multiple workflows may not be feasible.
Photo caption: Sequential Protein/DNA/RNA Extraction Kit
Photo credit: Thermo Fisher Scientific
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