This monoclonal Mouse anti-BCL-10 antibody clone (clone: 151) qualitatively detects BCL-10 in formalin-fixed paraffin-embedded tissue sections. It was raised against the recombinant full length human BCL-10 fusion protein.
BCL-10 is an apoptotic regulatory molecule identified through its direct involvement in mucosa-associated lymphoid tissue MALT lymphoma. It is also expressed in normal lymphoid tissue but doesn’t exhibit cross reaction with other tissues except breast.
Chromosomal translocation is a rare but recurrent abberation in mucosa-associated lymphoid tissue and has been found predominantly in this type of tumor. Molecular cloning has identified the involved gene. BCL 10 encodes a protein of 233 amino acids with residues 13-101 forming a caspase recruitment domain found in a number of apoptotic regulatory molecules. In non-malignant B-cell follicles the protein is expressed in the cytoplasm of the germinal center B-cells, while in MALT lymphomas with t(1;14)(p22;q32), BCL-10 expression could be detected both in nucleus and cytoplasm.
Zymed Laboratories Inc.
Keyword: antibody, lymphoma