The tech moves beyond traditional record-keeping to actively participate in experiment planning, design, and analysis.
Sapio Sciences has launched a third-generation Electronic Lab Notebook (ELN), Sapio ELaiN, featuring agentic AI technology that functions as a scientific collaborator rather than a passive documentation tool.
Sapio ELaiN represents a departure from traditional ELNs by incorporating AI agents that help plan, design, and analyze experiments while maintaining scientific rigor and compliance standards. The platform leverages both agentic and generative AI to work alongside scientists throughout the research process.
“Instead of merely recording and storing data, Sapio ELaiN acts as a new kind of agentic AI scientific collaborator, guiding scientists at every step,” says Kevin Cramer, CEO and CTO of Sapio Sciences, in a release. “It understands context, helps plan and design experiments, and analyzes results, always ensuring work is documented, repeatable, and compliant.”
Moving Beyond Traditional ELN Limitations
Traditional ELNs have primarily focused on recording and documenting research, with some recent tools adding data modeling and analysis capabilities. Sapio Sciences positions its AI Lab Notebook (AILN) as addressing limitations in usability and functionality that have left much of the research burden on scientists.
The platform is designed as an AI-native system with scientific fluency across research domains including cheminformatics, bioinformatics, and structure-based design. An expanding ecosystem of tools and agents captures every action with full provenance to ensure decisions remain explainable, repeatable, and compliant.
Integrated AI Capabilities
At launch, Sapio ELaiN includes several AI-powered capabilities integrated directly into the notebook workspace:
Molecular docking simulation for binding simulations between compounds and targets
Ad hoc data analytics for instant analysis and visualization of complex data tables
Codon optimization for genetic sequence optimization across different expression system
Small molecule analysis including retrosynthesis route planning, toxicity and solubility prediction, and buyability assessment
Protocol-based experimentation that builds and executes experiments from text-form protocol descriptions
The company plans to continuously add new scientific functions based on customer feedback and emerging research techniques.
Industry Implementation
Sapio Sciences reports that customers are already implementing AI to change laboratory efficiency. LabConnect recently launched LIMSConnect, based on the Sapio Platform, to replace manual workflows with a digital, AI-enabled environment designed for operational complexity.
The Baltimore-based company’s configurable AI-powered informatics platform includes LIMS, ELaiN, and Scientific Data Cloud components that aim to streamline workflows, unify scientific data, and support decision-making across biopharma research and development, clinical diagnostics, and manufacturing.
Sapio ELaiN is available for use immediately, with demonstrations available upon request.
