Fabric Genomics, a provider in AI-powered clinical next-generation sequencing (NGS) interpretation and reporting, announced a strategic collaboration with cloud-based data management pioneer DNAnexus to empower clinical laboratories, hospitals, and academic centers to rapidly access and analyze large-scale clinical whole genome data and bring vital clinical insights to patients.
Through the partnership, Fabric Genomics will integrate its advanced genomic analysis tools and AI engine with the DNAnexus Precision Health Cloud, providing users with a push-button solution to move quickly from sample to evidence-backed analysis to actionable clinical reports, the companies say. It interprets genomic sequences, detects clinically meaningful variants, and generates comprehensive patient reports. The workflow helps reduce overall analysis costs and significantly improves turnaround times from days to hours for a range of clinical rare genetic disorders and oncology diagnostics.
“Through this collaboration with Fabric Genomics, we are enabling customers to unlock critical clinical insights hidden inside large-scale, genomic datasets,” says Thomas Laur, CEO at DNAnexus. “Together, we will help accelerate scientific discovery and improve patient care.”
The Fabric Genomics interpretation and reporting platform is currently widely used in academic medical centers and commercial laboratories, such as Rady Children’s Institute for Genomic Medicine and the newly formed Broad Clinical Lab. DNAnexus actively manages and supports more than 80 petabytes of complex clinical genomic, proteomic, and other multi-omic datasets on behalf of a growing network of collaborations with leading pharmaceutical, clinical diagnostic, academic research, biobank, and government organizations. The comprehensive cloud platform meets rigorous industry standards for data quality, security, privacy, and regulatory compliance. Together, these tools instantaneously transform the cloud-sourced data into vital clinical insights, according to the companies. Reports generated by Fabric not only pinpoint candidate genes, but they also rank diagnoses based on a patient’s clinical information and probabilistic disease matching. This approach ensures that clinical teams can focus on the most plausible diagnoses to help optimize patient care.
“The technology advances and cost reduction in genomics sequencing is generating an even larger data management and analysis bottleneck for clinical genomics labs. Combining Fabric Genomics’ clinical expertise with the leading data management solution provided by DNAnexus, allows us to further clinical genomics,” says Martin Reese, PhD, CEO and co-founder of Fabric Genomics. “With more and more diversity in sequencing from short-read to long-read sequencing, an instrument neutral and flexible workflow engine to process diverse genomic data from different providers and different modalities, combined with a clinical workflow, we are providing the tools needed for any clinician to scale clinical genomics.”