Summary: MGI and SeqOne announced a collaboration to develop and validate comprehensive genomic analysis solutions for human genetics and pathology labs, integrating MGI’s sequencing technology with SeqOne’s AI-driven software.


  1. The collaboration aims to validate an automated, cost-effective workflow for HRD signature testing using MGI’s DNBSEQ-G99 sequencer and SeqOne’s somaHRD solution, ensuring high-quality and efficient pathology testing.
  2. MGI’s MegaBOLT bioinformatics accelerator will be integrated with SeqOne’s AI-powered analysis platform to provide a versatile, time-saving, and intuitive solution for high-throughput Human Genetics labs, covering Germline Panels, Whole Exome, and Whole Genome analysis.
  3. The SeqOne Platform will be technically validated for use with MGI sequencers, ensuring high performance in variant calling for Germline and Somatic analysis in routine diagnostic settings.

MGI, a company building tools and technologies that drive innovation in life science, announced a collaboration with SeqOne, a provider of AI-driven genomic decision support software, to develop and validate end-to-end genomic analysis solutions from sample to report tailored to the needs of human genetics and pathology labs worldwide.

This collaboration between MGI and SeqOne encompasses three distinct initiatives:

  1. Validating an end-to-end, automated, cost-effective solution for HRD signature with MGI DNBSEQ-G99

The collaboration between a Pathology Reference Lab in Spain, Agilent Technologies, MGI, and SeqOne aims to technically validate a routine workflow leveraging Agilent panels, Magnis lib prep automation, MGI DNBSEQ-G99, and SeqOne somaHRD, a clinically validated HRD signature solution, on 96 samples.

This end-to-end solution for pathology molecular labs will enable high-quality, efficient, and flexible HRD testing worldwide, including Genomic Instability score and BRCA testing.

  1. Enabling and validating SeqOne tertiary analysis solution compatible with MGI Megabolt for Germline Panels, Whole Exome, and Whole Genome

MegaBOLT bioinformatics analysis accelerator, self-developed and MPS-concentrated hardware accelerating system by MGI, is set to ensure seamless integration and compatibility with SeqOne’s AI-powered variants identification and analysis solution.

The collaboration aims to combine MegaBOLT and the SeqOne Platform to deliver a versatile, cost-effective, intuitive, and time-saving solution from sample to report, particularly attractive for high-throughput Human Genetics labs.

  1. Validating SeqOne CE-IVD Platform for Germline and Somatic analysis for use with MGI sequencers in routine diagnostics

This technical validation project aims to evaluate the compatibility of the SeqOne Platform with MGI sequencing data. It will validate variant calling performances on a set of reference control samples in terms of QC, sensitivity and precision.

“We are thrilled to announce our collaboration with SeqOne. By combining MGI’s cutting-edge sequencing technology with SeqOne’s innovative genomic analysis Platform, we are poised to deliver real insights and solutions for personalized healthcare,” says Yong Hou, PhD, General Manager of MGI Europe and Africa. “This collaboration underscores our commitment to advancing genomic research and providing clinicians with the tools they need to offer tailored treatments to their patients.”

Further reading: Single Genomic Test Aims to Accelerate Diagnoses for Rare Genetic Diseases

“This partnership with MGI strongly supports SeqOne’s mission to broaden access to sophisticated genomic analysis, aiming to improve healthcare outcomes,” says Martin Dubuc, CEO, SeqOne. “Molecular laboratories globally are exploring how MGI’s sequencing and bioinformatics technologies can advance next-generation sequencing (NGS) research and diagnostics. We are eager to integrate SeqOne’s CE-IVD Platform with MGI’s offerings, enhancing the quality, sensitivity, and precision of bioinformatic analyses.”