The Echo 650 Plus Series features updated electronics and a 54% reduction in power consumption to lower operating costs.


Beckman Coulter Life Sciences announced the commercial release of the Echo 650 Plus Series acoustic liquid handlers, featuring next-generation electronics and improved acoustic performance, according to a company release.

The new series offers a 54% reduction in power consumption compared to previous systems to support sustainability goals and lower operating costs in high-throughput laboratories, according to a release from the company.

“With the Echo 650 Plus Series, we focused on delivering measurable performance improvements that matter to our customers—greater reliability, lower operating costs, and smarter, real-time system intelligence,” says Sudarshana Seshadri, vice president of product management, Beckman Coulter Life Sciences, in a release. “These upgrades empower scientists to scale acoustic liquid handling with confidence, efficiency, and precision across demanding workflows.”

Enhanced Electronics and Reliability

The system includes a next-generation transducer with a titanium lens designed to simplify instrument power-down and recovery while reducing routine maintenance. This transducer stability removes the need for routine focus calibration adjustments, which helps maximize system uptime and minimize hands-on intervention, according to the company release.

New electronics architecture further improves system performance, real-time computational capability, and overall reliability, according to the company. These advancements reflect the application of continuous improvement and innovation principles to deliver performance gains at scale.

Machine Learning for Fluid Analysis

The series uses enhanced real-time processing to enable Dynamic Fluid Analysis 2 (DFA2). This technology uses machine learning-driven models and acoustic feedback to optimize Acoustic Droplet Ejection (ADE) performance.

DFA2 automatically accounts for variability in source plate manufacturing and evaluates fluid surface response before each droplet ejection to select the optimal ADE calibration for every well. According to the company, this adaptive approach improves fluid measurement accuracy, transfer reliability, and long-term consistency across various sample types.

The Echo 650 Plus Series is built on acoustic technology and is engineered to support demanding drug discovery applications.

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