Point-of-Care Test Device
Identify emerging drugs of abuse
TOX/See from Bio-Rad, Hercules, Calif, is a one-step, handheld, point-of-care test device for the qualitative detection of 14 drugs or drug metabolites in human urine. The TOX/See product portfolio includes specific tests for emerging drugs of abuse, such as oxycodone, buprenorphine, ecstasy, and propoxyphene, and features a variety of combinations of 14 drugs. The device offers simultaneous detection of as many as 12 drugs per cassette and can differentiate among amphetamine, methamphetamine, and ecstasy in one step. Test results are available within 5 minutes and remain stable for reading for up to 1 hour.
(510) 724-7000; www.bio-rad.com
Hydrocone Urine Test
The recently launched DRI Hydrocodone/Hydromorphone assay from Thermo Fisher Scientific, Fremont, Calif, is a homogeneous enzyme immunoassay that specifically detects hydrocodone and major metabolites in human urine at a 300 ng/mL cutoff. Hydrocodone is the most frequently prescribed opiate in the United States and is often prescribed in combination with acetaminophen (Vicodin). The assay utilizes liquid, ready-to-use reagents, calibrators, and controls, and can be run in qualitative and semi-quantitative modes. The assay has ?100% cross-reactivity to the major metabolites hydromorphone and hydromorphone glucuronide, and has demonstrated good correlation with LC-MS/MS and excellent assay precision. It is a sensitive, specific, and easy-to-use screening tool for hydrocodone and major metabolites in urine samples. For criminal justice and forensic use only.
Thermo Fisher Scientific
(800) 678-5599; www.thermofisher.com
CLIA-Waived Rapid Drug Testing
Results in 5 minutes
The Alere iCup Dx 14 from Alere, Waltham, Mass, is a CLIA-waived drug test cup. The urine drug test targets 14 illicit and prescription drugs and features a specimen validity test option that detects five common adulterants. The broad range of drugs tested, combined with low opiate cutoff levels and buprenorphine screening, make it a reliable choice for rapid clinical testing and occupational healthcare settings. Obtaining drug test results requires only three steps: collect the specimen and secure the lid, tilt the cup to activate, then read the results at 5 minutes. The self-contained cup design is suitable not only for sample collection, but for sending presumptive positive specimens to a laboratory for definitive confirmatory testing.
(800) 340-4029; www.aleretoxicology.com
Complete menu for drugs-of-abuse testing
The Viva-ProE system with Emit technology from Siemens Healthcare, Malvern, Pa, optimizes drug testing by delivering efficient results in a compact benchtop design. Onboard waste and water storage improve workflow, while a touch screen monitor with next-generation software improves efficiency. Up to 50 samples and 12 auxiliary positions enhance walkaway time and help reduce errors, while Peltier cooling ensures reagent stability and performance. Long-life components are designed to reduce user maintenance and limit periodic maintenance visits to one per year. The system includes a complete menu for drugs-of-abuse and validity testing and serum toxicology.
(888) 826-9702; www.usa.healthcare.siemens.com
Eliminates volumetric blood hematocrit bias
The research-use-only Mitra microsampling device from Neoteryx, a spin-off of Phenomenex, Torrance, Calif, is designed for the collection, transport, storage, and analysis of biological fluids. The microsampler consistently collects 10 µL of fluid within seconds while eliminating the volumetric blood hematocrit bias typically associated with the dried blood spotting technique. Based on proprietary volumetric absorptive microsampling technology, the design features facilitate high-throughput and serial sampling, fluid draws from live hosts or tubes, and the ability to collect precise microsamples with limited training and no specialized lab equipment. Once samples are collected, the microsampler is dried, stored, and transported under ambient conditions, eliminating the need for laborious and expensive processing steps. To prepare samples for analysis, an automatable extraction is performed with common solvents.
(310) 212-0555; www.phenomenex.com
Internal logic detects inconsistencies in admitted drug use
Windopath Toxicology software (WPTox) from Psyche Systems Corp, Milford, Mass, includes specific workflow and functionality for capturing, properly classifying, and interpreting the presence or absence of prescribed and nonprescribed drugs, as well as drugs of abuse. A web-based portal simplifies the sample-collection process by asking specific questions pertaining to the patient’s drug history, current admitted prescriptions, and use of any illicit drugs. The software’s internal logic then determines whether the presence or absence of certain metabolites is consistent with the information captured at the time of order. Report formats include the panel ordered, metabolites screened, cutoff values for each metabolite, and a specific summary section noting any findings inconsistent with the information initially provided. WPTox can be used as a stand-alone toxicology information system or as part of a complete pathology laboratory solution.
Psyche Systems Corp
(508) 473-1500; www.psychesystems.com
Improved lot-to-lot reproducibility
Novum simplified liquid extraction (SLE) from Phenomenex, Torrance, Calif, is a novel, synthetic alternative to traditional diatomaceous earth SLE products and a simplified approach to traditional liquid-liquid extraction (LLE). The patent-pending sorbent can be used with the same procedure as traditional SLE sorbents while delivering improved lot-to-lot reproducibility. Novum SLE simplifies the liquid-liquid extraction process by eliminating manual steps and reduces solvent consumption. SLE also delivers higher sample recovery than liquid-liquid extraction methods by eliminating analyte loss due to emulsions that can form at the interface of the two liquid phases. Novum SLE is available in 96-well plates featuring long-drip tips that extend into the wells to reduce contamination, with loading capacities of 200 µL and 400 µL.
(310) 212-0555; www.phenomenex.com
100% aqueous stability
Kinetex Core-Shell Biphenyl HPLC/UHPLC columns from Phenomenex, Torrance, Calif, provide researchers with orthogonal selectivity to traditional C18 phases. This new phase is suitable for a broad range of complex-mixture analyses in clinical research and forensic toxicology. Made with proprietary core-shell technology, the columns deliver better resolution, higher efficiency, sharper peaks, and greater sensitivity than traditional HPLC/UHPLC media. In addition to 100% aqueous stability and enhanced polar basic selectivity, the Kinetex 2.6 µm Biphenyl offers the greatest versatility for HPLC/UHPLC methods while the Kinetex 5 µm Biphenyl offers excellent HPLC performance at extremely low backpressures. Kinetex Biphenyl is available in 2.6 µm and 5 µm, with a 1.7-µm option expected next.
(310) 212-0555; www.phenomenex.com
Reagents for 18 highly complex drugs of abuse
MedTest DX, Canton, Mich, offers automated, fast, cost-effective testing solutions for pain-management and toxicology laboratories. The Mindray BS-200 analyzer is capable of running both drugs of abuse and general chemistries. The system accommodates reagents for comprehensive metabolic panels and ion-selective electrodes with space for 10 additional tests, and requires minimal startup and maintenance time. Dual power switches allow reagents to be stored on-board in a refrigerated compartment. Collision protection and liquid-level sensing ensure confidence in probe management. MedTest DX offers reagents for 18 highly complex drugs of abuse, including 6-acetylmorphine, amphetamine/methamphetamine, barbiturate, cannabinoid, cocaine metabolite, cotinine, ecstasy, ethanol, methadone, opiates, oxycodone, tricyclic antidepressants, and urine adulterants.
(866) 540-2715; www.medtestdx.com
Drugs of Abuse and Toxicology Testing
Expanding test menu
Beckman Coulter, Brea, Calif, offers a continually expanding menu of reagents, calibrators, and controls for drugs of abuse and toxicology testing, including acetaminophen, alcohol, amphetamines, barbituate serum tox, barbituates, benzodiazepine, benzodiazepine serum tox, buprenorphine, cannabinoid 100 ng, cannabinoid 20 ng, cannabinoid 50 ng, cocaine metabolite, ecstasy, methadone, methaqualone, opiates 2000 ng, opiates 300 ng, oxycodone, phencyclidine, propoxyphene, salicylate, and tricyclics serum tox. Tests run on the AU family of clinical chemistry analyzers or on UniCel DxC systems.
(800) 526-3821; www.beckmancoulter.com