This recently introduced ultra sensitive immunoassay test measures C-reactive protein (CRP) in serum. It can be applied to a variety of automated chemistry analyzers. The kit’s liquid-stable reagents, requires no preparation, mixing or dilutions, and no sample pre-dilution is required.
C-reactive protein is described in the literature as an acute-phase protein that is involved in the activation of complement, acceleration of phagocytosis and detoxification of substances released from damaged tissue. CRP is a sensitive indicator of inflammation and recent literature has suggested that measuring CRP levels can be useful in screening for cardiovascular events. The CRP Ultra is intended for the quantitative determination of human CRP by latex particle-enhanced immunoturbidimetric assay.
Its latex particles, coated with antibody specific to human CRP, aggregate in the presence of CRP from the sample forming immune complexes. The immune complexes cause an increase in light scattering, which is proportional to the concentration of CRP in the serum. The light scattering is measured by reading turbidity at 572nm, and the sample CRP concentration is determined versus dilutions of a CRP standard of known concentration. The assay for very low levels of C-reactive proteins is a stable reagent.
Keyword: reagent, C-reactive protein, cardiac