Global medical technology company BD recently launched its new BD Rhapsody TCR/BCR Multiomic Assay, a set of reagents designed to enable researchers to more easily and comprehensively analyze important cells in the immune system.

Multiomics is a rapidly developing field where researchers look at multiple types of molecules on the same cell, which can provide greater biological insights than the traditional approach of analyzing molecules in aggregate, across many cells. The new assay provides a tool to advance research in autoimmune disorders, immuno-oncology, and infectious diseases.

The BD Rhapsody TCR/BCR Multiomic Assay supplies immunology researchers the specific reagents required to profile full-length T cell and B cell receptors, two of the most important cellular elements in the immune system, to better understand the adaptive immune response and enable applications such as evaluating cellular responses to new drugs.

“Understanding the contribution of these heterogeneous cell subsets at the single-cell level is of extreme relevance,” says Susan Ribeiro, PhD, assistant professor, Emory University School of Medicine. “This coupling of single RNAseq/AbSeq along with TCR/BCR sequencing opens a new horizon for the understanding of the contribution of T and B cell receptors to the diversity of immune responses observed in people. The new BD Rhapsody TCR/BCR Multiomic Assay can be very helpful to guide the discovery of new therapeutic targets.”

The BD Rhapsody TCR/BCR Multiomic Assay has a wide range of applications, including screening for antigen specific cells in response to infectious diseases, immune repertoire profiling of tumor infiltrating lymphocytes, and vaccine development and evaluation of efficacy. The assay is optimized to work with the company’s BD Rhapsody Single-Cell Analysis System workflow, which enables higher capture rates than currently available solutions, preserving fragile cells in the process. This first-generation kit is now available globally and is the latest addition to the fast-growing portfolio of tools for multiomic analysis at BD.

“With the release of the BD Rhapsody TCR/BCR Multiomic Assay, we are reinforcing our commitment to the incredibly exciting field of multiomics and single-cell research and the delivery of robust, easy-to-use tools that offer researchers valuable and deep insights,” says Puneet Sarin, worldwide president at BD Biosciences. “Single-cell analysis tools like the BD Rhapsody TCR/BCR Multiomic Assay and BD Rhapsody Single-Cell Analysis System support our customers’ need for greater sensitivity and specificity studying cells of interest and drive rapid advancements in immunology, including research in therapeutic response and cell therapy.”

BD has continued to build on its BD Rhapsody Single-Cell Analysis System, a comprehensive portfolio of reagents, instruments, software and targeted gene panels, to offer additional single-cell analysis capabilities. These include the BD Rhapsody Whole Transcriptome Analysis Amplification Kit designed to analyze the entire transcriptome and targeted RNA panels. Importantly, all BD assays are multiomics enabled and allow researchers to simultaneously analyze protein and RNA information at the single-cell level.