Shimadzu Scientific Instruments, Columbia, Md, has introduced the LCMS-8060NX triple quadrupole liquid chromatography tandem mass spectrometer (LC-MS/MS). The new instrument features maximized sensitivity and acquisition speeds, increased robustness to minimize downtime, unparalleled ease of use for greater workflow efficiency, and analytical intelligence functions to maximize laboratory output. Newly developed ion-focus lenses in the integrated electrospray probe propel ions into the LCMS-8060NX efficiently. Neutral particles are expelled to reduce noise and provide the highest stability. A new heat-assist design increases desolvation efficiency and promotes superior ionization of a wide range of compounds. The system’s unique UFsweeper technology effectively sweeps ions from the collision cell without deceleration, to maintain high-sensitivity analysis even at high acquisition speeds. The LCMS-8060NX employs new ion guides, the UF-Qarray II and the UF-Lens II, to increase robustness while maintaining high ion transmission efficiency. Improved robustness means higher laboratory throughput as maintenance interval times increase. To further maximize productivity, consumable parts like the ESI spray needle and the inlet desolvation line can be changed quickly and easily without breaking vacuum. Designed for easy operation, the LCMS-8060NX incorporates optimized parameters based on artificial intelligence research that enable high sensitivity without manual optimization. Features such as automated start-up and shutdown (with LabSolutions Connect MRM) enable unattended operation. To complement the LCMS-8060NX, Shimadzu has also introduced updated LabSolutions LCMS workstation software for total operator support, from analysis to data processing. For more information, visit Shimadzu Scientific Instruments.