Summary: Illumina’s new MiSeq i100 Series sequencing systems provide faster, simpler, and more cost-efficient next-generation sequencing (NGS) solutions, enabling labs to deliver same-day results with room-temperature reagent storage and turnkey workflows.
Takeaways:
- Enhanced Speed and Flexibility: The MiSeq i100 systems offer run times as fast as four hours with same-day sample-to-analysis results, alongside room-temperature reagent storage for on-demand sequencing.
- Cost and Sustainability Benefits: The system reduces packaging waste by 85% compared to previous models, supporting a lower carbon footprint, while offering cost-effective consumables for affordable sequencing.
- User-Friendly Workflows: Designed with simplicity in mind, the push-button workflows and cloud-based data analysis minimize the need for advanced NGS or bioinformatics expertise, making the system accessible for labs of all experience levels.
Illumina, a provider in DNA sequencing and array-based technologies, unveiled its MiSeq i100 Series of sequencing systems, delivering improved benchtop speed and simplicity to advance next-generation sequencing (NGS) for labs.
The two new benchtop instruments, MiSeq i100 and MiSeq i100 Plus Systems, will empower customers to unlock powerful insights through an affordable, comprehensive solution that is simple to understand and use, even for those with limited NGS expertise. Room-temperature storage and shipping enable labs to sequence on demand, with no delays for thaw time, and same-day sample-to-analysis.
“Our customers told us they need a faster, smaller, and easy-to-use instrument, and that’s what we’re delivering with the MiSeq i100,” says Jacob Thaysen, PhD, CEO of Illumina. “Whether you are an established next-generation sequencing lab, or looking to start sequencing for the first time, our latest benchtop instrument adds the plug-and-play flexibility that today’s labs are seeking.”
The MiSeq i100 Series builds on the legacy of the original benchtop MiSeq System, which Illumina customers have used since 2011 to power a host of genomic discoveries. Completely redesigned and incorporating the groundbreaking technology and chemistry of the NovaSeq X Series, the MiSeq i100 will help to fuel the next era of genomics growth and discovery.
MiSeq i100 Series: Technology Enhancements
The MiSeq i100 Series brings Illumina’s powerful XLEAP-SBS chemistry innovation even further—for the first time, harnessing the potential of room-temperature storage and shipping, which provides customers greater flexibility in how they plan and execute their projects while reducing their environmental impact. It offers flexible output capabilities and comes in two configurations: the MiSeq i100 Plus System has the full 100 million single-end reads per run, and the MiSeq i100 System has a maximum of 25 million single-end reads per run. Key features include:
- Room-temperature shipping and storage for reagents: Eliminating the cold chain and allowing for greater flexibility to sequence on demand without the need to thaw reagents, which is critical for running urgent samples
- Sustainability: An 85% reduction in packaging waste compared to the MiSeq System supports a lower carbon footprint
- Speed: Dramatic reduction in run times: as fast as four hours, with same-day results (4× faster than MiSeq)
- Cost efficiency: Cost-effective consumables enable more affordable sequencing
- Turnkey workflows: 18 proven end-to-end workflows across 10 applications
- Simplicity: Simpler, streamlined operations for various levels of sequencing experience
Push-button workflows on MiSeq i100 are available for small whole-genome sequencing for microbiology and targeted NGS panels for both infectious disease and oncology. Workflows provide metrics either directly on the instrument or via cloud-based DRAGEN genomic data analysis, minimizing the need for bioinformatics expertise.
“The MiSeq i100 symbolizes Illumina’s commitment to delivering total systems with complete workflows that allow our customers to accomplish more,” says Steve Barnard, PhD, chief technology officer of Illumina. “With its enhanced speed, simplicity, scalability, and quality–and its intuitive user experience–the MiSeq i100 sets a new standard for benchtop sequencing.”
Featured image: The MiSeq i100 Series is Illumina’s fastest, simplest benchtop sequencers ever. Photo: Illumina