Summary: A new AI-based test assesses CD3 immune cells in early-stage bowel cancer tumors to predict recurrence risk, potentially helping patients avoid unnecessary chemotherapy.
Takeaways:
- AI Algorithm for Predicting Cancer Recurrence: The AI-driven CD3 Score test accurately assesses the number of CD3 immune cells in early-stage bowel cancer tumors, predicting which stage II cancers are most likely to recur within five years, and assisting clinicians in deciding which patients need further treatment.
- Clinical Benefits and Potential Impact: The test offers a more reliable method for determining the necessity of chemotherapy in early-stage bowel cancer patients, potentially reducing unnecessary chemotherapy treatments and helping patients and doctors make informed decisions post-surgery.
- Validated and Reliable Testing Method: The study demonstrated that tumors with higher CD3 scores were less likely to recur, and the test was found to be reliable when repeated in a second set of patients, providing a strong rationale for its adoption in clinical practice, potentially within the NHS.
A new artificial intelligence (AI) test to determine the risk of bowel cancers coming back could help patients avoid chemotherapy, according to new research led by the University of Leeds.
AI Algorithm Asses Immune Cells
The test uses an AI algorithm to accurately assess the number of immune cells known as CD3 inside early-stage bowel cancer tumours. Bowel cancer, also known as colorectal cancer, is found anywhere in the large bowel, which includes the colon and rectum. It is one of the most common cancers in the world, with 1.9m cases diagnosed in 2020. *
In the study, the CD3 Score test reliably showed which stage II cancers were most likely to recur within five years of surgery – and this could be used by clinicians to decide which patients may need further treatment such as chemotherapy.
“This has the potential to be the most important test patients with early-stage bowel cancer ask for. It’s fast, accurate and simple, and we hope it will make conversations about chemotherapy after surgery much more straightforward for patients and their doctors,” says Lead author Christopher Williams, PhD,Cancer Research UK Clinical Trials Research Fellow in the University of Leeds’ School of Medicine. Current methods for deciding which patients with early-stage bowel cancer need chemotherapy and which do not are unreliable. Many people receive chemotherapy when they don’t need it, and unfortunately some of the people who are not offered chemotherapy go on to experience cancer recurrence.
Williams continued: “It is very difficult to decide whether people with stage II colon cancer in particular need chemotherapy after their surgery as there is generally a lower risk that this cancer will come back. The assessment method we trialled gave a stronger indication than any feature we currently assess as to whether a stage II cancer might come back. This is very useful information for doctors and their patients facing difficult decisions about whether or not to proceed with chemotherapy after surgery.”
New Study Results
Previous studies have shown that bowel and rectal tumors with higher numbers of CD3 immune cells are less likely to recur after being removed by surgery. This is because CD3 cells can attack the cancer, helping the body tackle the disease.
“Our study underscores the potential importance of the CD3 Score test to bowel cancer patients, providing a critical insight to physicians in driving chemotherapy options for their patients,” says Kandavel Shanmugam, clinical research lead at Roche Tissue Diagnostics in Tucson, Arizona, who collaborated with the researchers at the University of Leeds’ School of Medicine.
Intensive Tumor Analysis
Researchers in the current study set out to establish whether the number of CD3 cells within tumors could be used to predict the risk of a tumor coming back after surgery.
They examined tissue from 868 bowel tumors at stage II and III to establish the numbers of CD3 cells within the tumors. The AI algorithm developed by the team calculated a ‘CD3 Score’ based on the number of CD3 cells in different areas of the tumor. High risk scores had lower numbers of immune cells, while low risk scores showed increased numbers of immune cells.
Tumors with a high-risk CD3 Score were three times more likely to have come back five years after surgery than those with a low-risk CD3 Score.
Recurrence rates were reduced in both groups when patients underwent chemotherapy, but the study also showed that patients with lower numbers of immune cells were the most likely to benefit from chemotherapy.
These findings can be used by doctors to decide whether a patient needs chemotherapy after bowel cancer surgery.
The CD3 Score test is patented by Roche Diagnostics.
“The CD3 Score test has been rigorously evaluated and found to be reliable when testing was repeated in a second set of patients,” Williams says. “The evidence generated by our trial of the usefulness and reliability of the CD3 Score test provides a clear rationale for its adoption by the NHS and our hope is that it will be made available to patients as soon as possible.”
