Spotlight on Hematology highlights the accuracy of mutation and variation detection using denaturing high-performance liquid chromatography (DHPLC) on the WAVE® System. Some traditional methods of mutation screening have been shown to be technically challenging or prohibitively expensive, or lacking sensitivity. DHPLC analysis on the WAVE System by temperature-modulated heteroduplex analysis was designed to offer a rapid, highly sensitive, automated, and cost-effective method for mutation screening.
Spotlight on Hematology includes discussions on using DHPLC and WAVE Systems to identify genetic variations in V-globin (HBB) alleles, hemophilia A, acute lymphoblastic leukemia, and protein C gene mutations.
Transgenomic Inc
www.CLPmag.com
