The spatial biology platform enables simultaneous detection of RNA and proteins in the same cell within a single automated workflow.
10x Genomics has launched Xenium Protein, a new addition to its Xenium Spatial platform that enables simultaneous RNA and protein detection in the same cell on a single tissue section within one automated run.
The platform represents the first fully integrated spatial multiomic workflow from 10x Genomics, allowing researchers to analyze both RNA and protein data without requiring separate technologies or complex data integration processes.
“Scientists can now analyze RNA and protein together, streamlining workflows, removing the need for complex data integration and unlocking more precise insights,” says Michael Schnall-Levin, founding scientist and chief technology officer at 10x Genomics, in a release. “Integrated multiomic analysis is essential to advancing our understanding of complex diseases and accelerating therapeutic discovery.”
Ready-to-Use Protein Subpanels
Xenium Protein expands the existing Xenium platform with ready-to-use protein subpanels that function alongside RNA panels on the same slide. The initial subpanels include dozens of characterized proteins involved in cell growth, signaling, and immune response, targeting applications in cancer research, immunology, and other disease areas.
The integrated approach eliminates the need for separate workflows, technologies, or sample sections, simplifying experimental design and reducing time to results. Early access customers are using the platform across discovery research, translational studies, and large-scale atlasing projects.
“Integrating RNA and protein analysis within the same Xenium workflow enables a view of tissue architecture and cell-cell interactions in a single experiment,” says Dr Julien Tessier, principal scientist at Sanofi, in a release. “This integrated multiomics approach removes the reliance on data co-registration – which is often complex and can introduce uncertainty—while delivering critical insights into target and biomarker expression that RNA alone often fails to capture.”
Xenium Protein is now available globally through 10x Genomics’ commercial channels.
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