2020_06_01_17_08_9519_2020_05_29_timsTOF-fleX_MALDI2_20200601171938Bruker, Billerica, Mass, has advanced the field of matrix-assisted laser desorption ionization (MALDI) with its launch of the first commercial MALDI-2 post-ionization source, which is now available as an option on the TimsTOF Flex electrospray ionization/MALDI mass spectrometer. The novel MALDI-2 technology can offer one or two orders of magnitude higher sensitivity for many small molecules and lipids, and it also increases the range of applications. MALDI-2 requires a second laser (266 nm) fired orthogonally into the expanding MALDI plume that is generated by Bruker’s proprietary primary SmartBeam 3-D (355 nm) laser. “In the last 35 years, MALDI has become a unique and rapid analytical tool for a wide variety of applications,” says Klaus Dreisewerd, PhD, section leader for biomedical mass spectrometry at the University of Muenster and the pioneer of MALDI-2. “We developed MALDI-2 to significantly extend the technique by providing much higher sensitivity for small molecules and the inclusion of chemical classes that did not ionize efficiently with MALDI. The MALDI-2-powered TimsTOF Flex will take MALDI to new scientific and analytical frontiers.” For more information, visit Bruker.