IBM Watson Health, Cambridge, Mass, and Quest Diagnostics, Madison, NJ, have launched IBM Watson Genomics from Quest Diagnostics, a new service that combines genomic tumor sequencing with cognitive computing to advance precision medicine. Memorial Sloan Kettering Cancer Center (MSK), will supplement Watson’s corpus of scientific data with OncoKB, an oncology knowledge base designed to help inform precision treatment options for cancer patients.
The launch marks the first time that Watson for Genomics has been made widely available to patients and physicians across the country. The Broad Institute of MIT and Harvard will provide additional genome sequencing capabilities as part of the collaboration.
The new service begins with laboratory sequencing and analysis of a tumor’s genomic makeup to reveal mutations that can be associated with targeted therapies and clinical trials. The Watson system then compares those mutations against relevant medical literature, clinical studies, pharmacopeia, and carefully annotated rules created by leading oncologists, including those from MSK. Watson for Genomics ingests approximately 10,000 scientific articles and 100 new clinical trials every month.
“The beauty of Watson is that it can be used to dramatically scale access to knowledge and scientific insight, whether a patient is being treated in an urban academic medical center or a rural community clinic,” says John E. Kelly III, PhD, senior vice president at IBM research and cognitive solutions. “Through this collaboration with the cancer community’s leading clinical and pathology experts, thousands more patients can potentially benefit from the world’s growing body of knowledge about this disease.”
Bolstering the corpus of data Watson uses, MSK will provide OncoKB, a database of clinical evidence that will help Watson uncover treatment options that could target the specific genetic abnormalities that are causing the growth of the cancer. Comparison of literature that might have taken medical experts weeks to prepare can now be completed in significantly less time.
“Precision medicine is changing the way we treat cancer and giving new hope to people living with the disease,” says Jay G. Wohlgemuth, MD, chief medical officer and senior vice president of research, development, and medical, at Quest Diagnostics. “However, access to genomic sequencing and tumor analysis required to determine appropriate precision medicine treatments for a patient can be a challenge. This service combines Quest’s state-of-the-art tumor analysis and national access with the cognitive computing of IBM’s Watson and the deep cancer treatment expertise of MSK. This is a powerful combination that we believe will leapfrog conventional genomic services as a better approach for identifying targeted oncology treatments.”
To access Watson’s evidence-based report, the treating oncologist or other physician will send a patient’s solid tumor biopsy tissue to Quest Diagnostics, where pathologists will prepare the tissue sample for genomic sequencing. Scientists at Quest will then sequence the treatment-associated genes using next-generation sequencing technologies and feed the genetic file into Watson. Watson will use the sequenced genetic data and compare those data against massive bodies of clinical, pharmacological, and scientific databases to uncover potential therapeutic options that match the patient’s tumor mutations. A Quest pathologist will review and validate the results and prepare a report to send back to the treating physician.
“We now know that genetic alterations are responsible for many cancers, but it remains challenging for most clinicians to deliver on the promise of precision medicine since it requires specialized expertise and a time-consuming interpretation of massive amounts of data,” says Paul Sabbatini, MD, deputy physician-in-chief for clinical research at Memorial Sloan Kettering Cancer Center. “Through this collaboration, oncologists will have access to MSK’s expertly curated information about the effects and treatment implications of specific cancer gene alterations. This has the power to scale expertise and help improve patient care.”