A recombinant CENP-B antigen is now available from the Binding Site Inc, San Diego. Designed for use as a critical component in ELISA-based test procedures, the antigen can be utilized to detect anti-centromere autoantibodies in human serum. Anti-centromere antibodies are most often found in patients with a form of systemic sclerosis formerly known as CREST syndrome, as well as Raynaud’s phenomenon and other rheumatic diseases such as systemic lupus erythematosus, rheumatoid arthritis, and Sjögren’s syndrome. CENP-B is generally considered the major centromere antigen. This antigen comprises a full-length, human-sequence protein expressed and purified in Sf9 insect cells. Demonstrating a purity level in excess of 90%, it is available in fill formats of 0.2mg and 1.0mg vials. For more information, visit the Binding Site.