Two new Certified Spiking Solutions for the nicotine metabolites anabasine-D4 HCl and trans-3’-Hydroxycotinine-D3 are now available from Cerilliant at concentrations of 100 ?g/mL in methanol. The solution standards can be used as internal standards spiked into patient samples or in isotope dilution methods for quantification of anabasine and 3-hydroxycotinine levels in nicotine screening and other clinical or diagnostic testing applications by GC/MS, LC/MS, or LC-MS/MS.

According to the Centers for Disease Control and Prevention, tobacco use causes 443,000 adult deaths annually. “As more laboratories are receiving calls to test for nicotine and nicotine metabolites, the demand for fully characterized, highly pure certified reference materials increases,” said Mitzi Rettinger, vice president of Cerilliant. “These new internal standards are produced to the highest industry guidelines in our convenient Snap-N-Spike format that maximizes laboratory throughput.”

Snap-N-Spike certified reference materials are available from Cerilliant for the major tobacco alkaloids, metabolites, and nitrosamines, including NNN, NNK, NNAL, and NAB, in addition to native and stable labeled internal standards of nicotine, cotinine, nornicotine, trans-3’-hydroxycotinine, and anabasine. The standards are appropriate for clinical toxicology, clinical and diagnostic testing, nicotine screening, and environmental monitoring applications. For more information, visit Cerilliant.