For many modern analytical laboratories, high-throughput analysis is pivotal. LC-MS/MS shows enormous capabilities for increasing sample throughput by monitoring multiple analytes simultaneously. Over the duration of the method, the time frames used for injection, column wash, and column equilibration time frequently represent a waste of time which negatively affects the throughput of the analysis. A multi-channel LC configuration can provide the capability to maintain the same analytical conditions while increasing sample throughput by reducing the detector idle time. The Nexera QX, a two-channel system coupled with a triple quadrupole MS detector, provides reliable and robust results running an LC-MS/MS method on two parallel flow lines and contributes to effortless usability in increasing the overall analytical throughput.