LipoScience Inc, Raleigh, NC, recently presented key findings related to lipoprotein particles (LDL-P) and cardiovascular disease at the annual meeting of the American Heart Association (AHA).
Low density lipoprotein cholesterol levels (LDL-C) do not always provide an accurate assessment of overall heart health. LDL-P are also a key factor in cardiovascular disease (CVD) management. Elevated LDL-P cause plaque buildup in the arteries, which in turn leads to heart attacks and other CVD events. LDL-P is a key component of the company’s NMR LipoProfile® test, which provides physicians and their patients with actionable information to personalize management of heart disease risk.
Hector Malave, MD, Cardiology of Atlanta, presented results from a study that illustrates the effect that lipid-lowering medications have on LDL-P in patients with angiographic coronary artery disease. The study evaluated 83 patients with elevated LDL-P levels and concluded that the majority of these patients treated with lipid-lowering medication for angiographic coronary artery disease had achieved target LDL-C levels, but many had failed to achieve LDL-P goals. The results suggest that these patients may still harbor risk for cardiovascular events based on their elevated LDL-P concentrations.
Donald Lynch, MD, of Vanderbilt Heart, also presented data focused on the effects of LDL apheresis on lipoprotein particle concentrations as determined by nuclear magnetic resonance (NMR). The study found that LDL apheresis reduced LDL-P by 67%, while high-density lipoprotein particle number (HDL-P) increased slightly in the study population, although the increase was not statistically significant. The primary effect of apheresis was significant reduction of apoB-containing lipoprotein particles (LDL and VLDL), with little effect on HDL-P.
“The data presented during AHA further validate the critical role of lipoprotein particles in managing cardiovascular disease risk,” said Robert Honigberg, MD, chief medical officer and vice president, medical affairs, LipoScience. “Physicians should be aware of the need to test and explore ways to lower LDL-P to help reduce residual cardiovascular risk for patients and recommend appropriate treatment plans. Directly measuring LDL-P with the NMR LipoProfile test enables physicians to gain a more complete picture of heart health.”