Researchers at the Texas A&M College of Medicine have discovered that dormant cancer cells may camouflage themselves from treatment because they have cannibalized the body’s own stem cells.1
The team had been working on teaching adult stem cells from bone marrow, called mesenchymal stem/stromal cells (MSCs), to fight cancer when they noticed that the MSCs were disappearing from the cell cultures.
Thomas J. Bartosh, PhD, Texas A&M College of Medicine.
“We actually thought we made a mistake or were witnessing an anomaly or negative result,” says Thomas J. Bartosh, PhD, assistant professor at the Texas A&M College of Medicine and first author of the study. “We eventually realized that the breast cancer cells were eating the stem cells. What was really interesting was what happened next: the breast cancer cells that had taken in the stem cells went dormant—essentially became ‘sleepy’—but at the same time they became much more difficult to kill.”
Bartosh and the team realized that if breast cancer cells in the body behave the same way, it might explain cancer recurrence.
Cancer cells that have cannibalized MSCs are highly resistant to chemotherapy and nutrient deprivation, strategies that fairly effectively kill other cancerous cells. Because there are only a few of them, the surviving cells are not detected with existing scanning methods. “Then one day, when conditions are right, the cells ‘wake up’ and start growing again,” Bartosh says. “This is when the cancer recurs, and because the cells are treatment-resistant, the recurrence can be very difficult to combat.”
Now that a possible mechanism for recurrence has been explained, the hope is that a treatment can be found that would keep the cannibalistic cells dormant, and doing no harm, for the rest of the person’s life. Another possible avenue for drug development would be something that would stop breast cancer cells from eating MSCs in the first place. Bartosh and the team are also working on exploiting the cannibalistic activity of some cancer cells to potentially feed them toxic agents, using MSCs as the delivery vehicle that can target cancer cells specifically, like a tumor-seeking missile.
“The biology of the process is intriguing,” Bartosh says. “It’s one mysterious phenomenon—cell cannibalism—that might help explain another mysterious phenomenon: tumor dormancy. If these findings do translate to humans, the implications for patients would be enormous.”
REFERENCE
- Bartosh TJ, Ullah M, Zeitouni S, et al. Cancer cells enter dormancy after cannibalizing mesenchymal stem/stromal cells (MSCs). Proc Natl Acad Sci. 2016;113(2):E6447–E6456; doi: 10.1073/pnas.1612290113.
