Two biomarkers widely being investigated as predictors of heart and vascular disease appear to indicate risk for “silent” strokes and other causes of mild brain damage that present no symptoms, report researchers from The Methodist Hospital, Houston, and several other institutions in an upcoming issue of Stroke (now online), which ispublished by the American Heart Association and American Stroke Association.
The researchers found high blood levels of troponin T and NT-proBNP were associated with as much as 3 and 3.5 times the amount of damaged brain tissue, respectively. The findings are part of the large-scale Atherosclerosis Risk in Communities (ARIC) study, funded by the National Heart, Lung, and Blood Institute.
“The concept of prevention is expanding,” says principal investigator Christie Ballantyne, MD, director of the Center for Cardiovascular Disease Prevention at The Methodist Hospital. “It’s not good enough to simply do a few tests and try to assess risk for heart attack. What we need to do is assess the risk for heart attack, stroke, heart failure, and also asymptomatic disease so we can start preventive efforts earlier. Waiting to correct problems until after a symptomatic stroke may be too late.”
For the subclinical brain disease study, researchers gleaned data from about 1,100 patient volunteers who agreed to have blood drawn and two MRI scans 11 years apart to look for silent brain infarcts and also white matter lesions (WMLs) caused by chronic inflammation.
One possible outcome is that patients determined to be in high-risk groups could be started on anti-stroke medications sooner.
In another ARIC paper published 2 months ago in Stroke, Ballantyne and coauthors reported a strong association between blood levels of troponin T and NT-proBNP and more severe instances of stroke, called symptomatic stroke. The current study looked at the two biomarkers and “subclinical,” asymptomatic events in the brain that are usually caused by a lack of blood flow.
“Taken together, these two papers show the biomarkers are effective at identifying people who are likely to have mild brain disease and stroke well before damage is done,” says Ballantyne, who also is a professor at Baylor College of Medicine, Houston. “This hopefully will give doctors more time to help patients take corrective steps to protect their brains.”
The Center for Cardiovascular Disease Prevention is part of the Methodist DeBakey Heart & Vascular Center.
The study was funded with grants from NHLBI and NIH, while Roche Applied Science helped fund the development of diagnostic technology.
[Source: The Methodist Hospital]