The new systems and software updates aim to improve sample analysis and data interpretation in research, drug development, and safety testing.
Thermo Fisher Scientific introduced three new mass spectrometry (MS) Orbitrap platforms, artificial intelligence (AI)-enabled software, and integrated workflows at the American Society for Mass Spectrometry Conference. The company’s expanded portfolio is designed to help laboratories manage complex samples and larger data sets in research, biopharma, and applied testing environments.
“Orbitrap technology has long set the standard for breakthrough discovery, and customers now want that same confidence across applied scientific markets,” says Ronald Tabaksblat, president, chromatography and mass spectrometry, Thermo Fisher Scientific, in a release.
Research and Disease Insight
The new Orbitrap Tribrid Apex MS is designed for researchers studying complex biological samples, further expanding the company’s range of innovative mass spectrometers. The platform includes three mass analyzers, a new infrared laser option for alternative fragmentation, and a Direct Mass Technology mode. These features are intended to provide clearer answers earlier in the discovery process.
Thermo Fisher also expanded its software capabilities through the acquisitions of MSAID and Proteinaceous. MSAID provides AI-driven proteomics and machine learning, while Proteinaceous adds top-down and native MS bioinformatics. New software updates include Proteoform Studio for streamlined proteomics workflows and Proteome Discoverer 3.4 for managing multiple workflows with increased flexibility and speed. These software advancements complement Thermo Fisher’s collaborative work in the field, such as its partnership on the Singapore Proteomics Study.
Biopharmaceutical Development
For drug development, the company unveiled the Orbitrap Excedion MS. This platform includes enhanced dynamic range technology, which can detect three to five times more compounds in complex samples compared to previous versions. Laboratories can upgrade to the Orbitrap Excedion Pro MS without replacing the entire instrument, which the company says minimizes costs and disruption to ongoing work.
Additional tools for biopharmaceutical labs include the Vanquish Amplify ultra-high performance liquid chromatography systems, which use a metal-free sample flow path to minimize sample loss. The company also introduced SurePac RP MDi columns for therapeutic analysis and the SMART Digest OligoSelect kit to simplify sample preparation. BioPharma Finder 5.5 software was also released to speed the processing of complex MS data.
For later-stage drug development, the TSQ Certis Triple Quadrupole MS is designed for regulated bioanalysis and quality control. According to the company, the system can measure samples 15% faster and operate more than twice as long between maintenance events when analyzing complex matrices like plasma.
Food and Environmental Safety
The Orbitrap Exploris GC S MS is a high-resolution gas chromatography-mass spectrometry platform designed for the analysis of dioxins and persistent organic pollutants, following the lineage of the previously released Orbitrap Exploris GC 240 mass spectrometer. The system provides the sensitivity required for ultra-trace results and helps laboratories identify emerging contaminants without requiring additional instrumentation.
Thermo Fisher also showcased the Orbitrap Exploris EFOX mass detector for screening pesticides and contaminants, along with the TSQ Altis Plus EFOX triple quadrupole MS for high-throughput quantitation. These systems are intended to help environmental and water safety laboratories detect risks and make public health decisions.
Photo caption: Thermo Fisher Scientific is introducing three new Thermo Scientific Orbitrap platforms.
Photo credit: Thermo Fisher Scientific
