The Callisto Complete Kit combines digital fluidics automation with sample preparation chemistry to deliver PCR-free whole genome sequencing workflows.
Volta Labs and Watchmaker Genomics announced the launch of the Callisto Complete Kit for DNA EF Library Prep at the Advances in Genome Biology and Technology General Meeting 2026 in Orlando, Florida.
The new solution pairs Watchmaker Genomics’ next-generation sequencing sample preparation chemistry with Volta’s digital fluidics automation to deliver a fully automated, PCR-free whole genome sequencing library preparation workflow.
As whole genome sequencing continues to expand across clinical research and translational settings, PCR-free workflows are increasingly preferred to minimize amplification bias, reduce sequencing artifacts, and enable more uniform genome coverage, particularly in GC-rich regions. However, executing PCR-free library preparation demands precision and reproducibility, making automation critical for labs seeking consistent results without increasing staffing burden.
By eliminating manual liquid handling and reducing operator variability, the Callisto Complete Kit aims to enable laboratories to generate reproducible, high-quality libraries while freeing technical staff to focus on higher-value work.
“We designed Callisto to make sequencing sample preparation simpler and more accessible,” says Udayan Umapathi, CEO of Volta Labs, in a release. “With the Callisto Complete Kit for DNA EF Library Prep, powered by Watchmaker chemistry, labs can run PCR-free whole genome sequencing workflows in a push-button format, delivering consistent, high-quality results in a practical mid-throughput range.”
Targeting Mid-Throughput Clinical Labs
The kit specifically targets clinical and translational laboratories that require push-button solutions with dependable performance but do not operate at a high-throughput scale.
“PCR-free whole genome sequencing demands both high-performance chemistry and workflow precision,” says Trey Foskett, CEO of Watchmaker Genomics, in a release. “For clinical and translational laboratories that require push-button solutions with dependable performance but do not operate at a high-throughput scale, the Callisto Complete Kit offers a simple and streamlined path to implementing PCR-free WGS with confidence.”
To mark the launch, Volta Labs and Watchmaker Genomics hosted a joint breakfast suite presentation at AGBT 2026 on Feb 24, where attendees could learn more about the Callisto Complete Kit for DNA EF Library Prep, see the automated PCR-free whole genome sequencing workflow in action, and hear from both teams.
Photo caption: Callisto Complete Kit
Photo credit: Volta Labs/Watchmaker Genomics
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