Shimadzu Scientific Instruments, Columbia, Md, has launched a new clinical laboratory automation module, CLAM 2030, a fully integrated pretreatment module for specimens undergoing biological analysis by liquid chromatography–mass spectrometry (LCMS). The automation module improves laboratory efficiency; enables fast, precise results; and maintains low operating costs.

By automating operations such as dispensing, stirring, filtering, heating, and sample transfer, the system effectively improves data accuracy and achieves the reproducibility needed for clinical research and forensic toxicology. Such steps can be combined to perform tasks such as deproteination, internal standard addition, derivatization, and glucuronidase digestion.

The CLAM 2030 makes it easier for users to reproducibly prepare samples and operate an LCMS regardless of their skill level. With a streamlined workflow that interfaces with laboratory information systems, the system enables users to easily create and run sample batches with minimal effort. Stat or emergency sample functionality enables users to prioritize urgent samples for quick results with minimal interruption.

The system also offers a variety of functions that elevate research and business efficiency, as it automates such processes as searching toxicological drug libraries, providing the optimal analytical method, facilitating data review, and generating reports. The CLAM 2030 can measure hundreds of compounds in a single analysis and makes it easy to change between different methods. Its flexible high-pressure liquid chromatography and mass spectrometry configuration also allows the unit to meet specific application needs.

Through automation, the CLAM 2030 also supports a safe working environment for laboratory personnel by minimizing human contact with potentially hazardous biological samples. Following pretreatment, solid and liquid waste are contained and collected within the body of the CLAM 2030.

Optional liquid chromatography–tandem mass spectrometry toxicology screening software includes methods for simultaneously or individually analyzing 161 analytes, including drugs of abuse, hypnotics and sedatives, natural toxins, pesticides, pharmaceuticals, and psychiatric and neurological drugs.

For further information, visit Shimadzu Scientific Instruments.