May 8, 2007
Ortho-Clinical Diagnostics has initiated a voluntary, nationwide recall of two lots of a reagent pack because of shifts in test results that could contribute to a missed diagnosis of myocardial infarction.
The company initiated the voluntary recall of the VITROSR Immunodiagnostic Products Troponin I Reagent Pack, Lots 3151 and 3170, after a small number of clinical laboratories administering the test reported shifts in quality control results. An investigation by Ortho-Clinical Diagnostics determined that the potential existed for false negative troponin-I results at very low levels of troponin elevation. A false negative test result would indicate that a person has not had a heart attack or heart muscle injury when in fact they have.
The recall is limited to the VITROSR Immunodiagnostic Products Troponin I Reagent Pack, Lots 3151 and 3170. Clinical labs in possession of these lots have been contacted via phone, fax, and overnight mail by the company and instructed to discontinue use of this product and notify healthcare providers who ordered the test in recent weeks. The identified product lots were distributed to clinical labs in the United States and outside the U.S. between January and March of 2007. Replacement product has been provided to clinical labs with the affected product lots.
Ortho-Clinical Diagnostics is working to identify the root cause of the reported issue and has reported the action to the FDA.