The Thermo Scientific Cascadion SM clinical analyzer from Thermo Fisher Scientific, Vantaa, Finland, is now commercially available in the United States with the Cascadion SM 25-Hydroxy Vitamin D assay.
Designed to deliver accurate, traceable measurements of vitamin D2 (ergocalciferol) and D3 (cholecalciferol), the serum assay reports total vitamin D results alongside its components. Clinical laboratories can now benefit from a complete system bringing the accuracy, sensitivity, and specificity benefits of Thermo Fisher’s gold standard liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology into routine clinical workflows.

Incorporating sample processing, LC separation, and MS detection capabilities in a single solution, the Cascadion system is fully automated and enables load and walk away sample management, eliminating the need for multiple connected components. The system offers end-to-end automation that is easy to use by any qualified laboratory personnel with minimal training.

The Cascadion system analyzes samples directly from qualified primary blood collection tubes, while the Cascadion SM 25-Hydroxy Vitamin D assay incorporates fully barcoded components, all traceable to a specific result. The vitamin D calibrators and controls are traceable to National Institute of Standards and Technology standards, and assay calibration remains stable for up to 30 days.

“The Centers for Disease Control and Prevention has established LC-MS/MS as the reference method for vitamin D testing,” says Bill Östman, vice president and general manager for Thermo Fisher Scientific. “However, LC-MS/MS has traditionally been a sophisticated technology, requiring specialized knowledge and significant hands-on time for method development. We developed the Cascadion system and the ready-to-use, prevalidated 25-Hydroxy Vitamin D assay to simplify and accelerate the implementation of LC-MS/MS in clinical settings without the need for extensive technical expertise.”

For more information, visit Thermo Fisher Scientific.