The Chromeleon 7.4 platform consolidates single quad, triple quad, and high-resolution accurate mass analysis workflows into an enterprise-ready system.


Thermo Fisher Scientific has launched Chromeleon 7.4 software, an enterprise- and compliance-ready chromatography and mass spectrometry data system designed to handle single quad, triple quad, and high-resolution accurate mass analysis in both regulated and non-regulated laboratory environments.

The platform aims to address challenges laboratories face when processing large volumes of mass spectrometry data by consolidating complex workflows into a single, networked system. Traditional mass spectrometry software applications typically operate on individual workstations, requiring scientists and lab managers to move between offices to view data locally or manually transfer data between storage devices, according to a release from the company.

“Mass spectrometry generates large volumes of data, which can be challenging to process and analyze efficiently; as a result, laboratories often struggle to quickly produce insights and may experience errors that result from manual data management,” according to the company.

Enterprise-Ready Network Operation

Chromeleon 7.4 handles networked operations, including concurrency management, network failure protection, and consistent processing of all mass spectrometry analyses. The system enables remote data access and instrument control, allowing scientists to share data across laboratories using the same software platform.

The platform includes improved visualization of single-scan fragments, allowing users to examine breakdown products of analytes for molecular structure insights. Simulated isotopic patterns help identify and confirm specific isotopes for quantitation and result validation.

Chromeleon 7.4 provides centralized data storage with full traceability through audit trails, electronic signatures, and secure user management to support GxP/21 CFR Part 11 compliance requirements.

The software supports mass spectrometry-based targeted screening and quantitation workflows across applications including bio/pharma research, PFAS analysis, and pesticide testing. The scalable technology delivers centralized data storage, remote instrument control, and multi-consensus reporting capabilities.

By streamlining workflows and standardizing software usage across laboratory setups, the system aims to reduce the need for scientists to learn multiple disconnected software systems when transitioning between different lab configurations.

Photo caption: Chromeleon

Photo credit: Thermo Fisher Scientific